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tseng al  (Gilead Sciences)

 
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    Gilead Sciences tseng al
    Tseng Al, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 99/100, based on 15537 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tseng+al/VEKLURY/pm36823658-98-12-21
    Average 99 stars, based on 15537 article reviews
    tseng al - by Bioz Stars, 2026-09
    99/100 stars

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    other:

    Article Title: Monoclonal antibody infusion reaction with bamlanivimab and etesevimab in a 5-year-old male with coronavirus disease 2019: a case report.
    Article Snippet: Nhean S, Varela ME, Nguyen YN, Juarez A, Huynh T, Udeh D, Tseng AL. COVID-19: a review of potential treatments (corticosteroids, remdesivir, tocilizumab, bamlanivimab/etesevimab, and casirivimab/imdevimab) and pharmacological considerations.



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    CYP3CIDE-selective inhibition of CYP3A4 and CYP3A5 and dose response in cell lines. (A) CYP3CIDE inhibition of CYP3A4 and CYP3A5 enzymatic activity. CYP3CIDE has a higher affinity on CYP3A4 inhibition than on CYP3A5 inhibition. The substrate in this experiment was MDZ, and the products of the reactions were 1-OH MDZ and 4-OH MDZ. (B) CYP3CIDE dose-response curve in HuH-7 (CYP3A5 *3/*3) and CYP3A5 *1/*1 dd cell lines with the 1-OH MDZ product as metabolite. The concentration of 50 µM CYP3CIDE was chosen for further study in other cell lines.

    Journal: Drug Metabolism and Disposition

    Article Title: CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism

    doi: 10.1124/dmd.117.076307

    Figure Lengend Snippet: CYP3CIDE-selective inhibition of CYP3A4 and CYP3A5 and dose response in cell lines. (A) CYP3CIDE inhibition of CYP3A4 and CYP3A5 enzymatic activity. CYP3CIDE has a higher affinity on CYP3A4 inhibition than on CYP3A5 inhibition. The substrate in this experiment was MDZ, and the products of the reactions were 1-OH MDZ and 4-OH MDZ. (B) CYP3CIDE dose-response curve in HuH-7 (CYP3A5 *3/*3) and CYP3A5 *1/*1 dd cell lines with the 1-OH MDZ product as metabolite. The concentration of 50 µM CYP3CIDE was chosen for further study in other cell lines.

    Article Snippet: CYP3CIDE ( Walsky et al., 2012 ; Tseng et al., 2014 ) (Sigma-Aldrich) was used as a selective CYP3A4 inhibitor in cell cultures and diluted in dimethylsulfoxide.

    Techniques: Inhibition, Activity Assay, Concentration Assay

    Effect of CYP3CIDE on MDZ metabolism in CYP3A5 genetically modified cells. Cells were treated with (gray bars) or without 50 µM CYP3CIDE (black bars) and assayed for MDZ metabolism. Each column in (C–E) represents six biologic replicates of a representative experiment. (C) MDZ disappearance by cell lines after incubation of MDZ in the presence of CYP3CIDE. (D) Production of 1-OH MDZ by cell lines in the presence of CYP3CIDE. (E) Production of 4-OH MDZ by cell lines in the presence of CYP3CIDE. P values in (C–E) were calculated based on the paired two-sample t test comparing with or without CYP3CIDE are ns, not significant; P > 0.05; *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.

    Journal: Drug Metabolism and Disposition

    Article Title: CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism

    doi: 10.1124/dmd.117.076307

    Figure Lengend Snippet: Effect of CYP3CIDE on MDZ metabolism in CYP3A5 genetically modified cells. Cells were treated with (gray bars) or without 50 µM CYP3CIDE (black bars) and assayed for MDZ metabolism. Each column in (C–E) represents six biologic replicates of a representative experiment. (C) MDZ disappearance by cell lines after incubation of MDZ in the presence of CYP3CIDE. (D) Production of 1-OH MDZ by cell lines in the presence of CYP3CIDE. (E) Production of 4-OH MDZ by cell lines in the presence of CYP3CIDE. P values in (C–E) were calculated based on the paired two-sample t test comparing with or without CYP3CIDE are ns, not significant; P > 0.05; *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.

    Article Snippet: CYP3CIDE ( Walsky et al., 2012 ; Tseng et al., 2014 ) (Sigma-Aldrich) was used as a selective CYP3A4 inhibitor in cell cultures and diluted in dimethylsulfoxide.

    Techniques: Genetically Modified, Incubation